Our people

Dr Nolan Hoffman

Postdoctoral Research Fellow
Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research

Areas of expertise: metabolism; skeletal muscle physiology; molecular transducers of exercise; cell signalling; cellular energy sensing; AMP-activated protein kinase (AMPK) biology; glycogen; insulin; glucose transport; obesity; insulin resistance; type 2 diabetes; human and rodent integrative physiology; cell biology; molecular biology; phosphoproteomics; proteomics; metabolomics

HDR Supervisor accreditation status: Full

ORCID ID: 0000-0001-5168-7082

Phone: +61 03 9230 8277

Email: nolan.hoffman@acu.edu.au

Location: ACU Melbourne Campus

Dr Nolan Hoffman is a Postdoctoral Research Fellow at Australian Catholic University (ACU) based at the Mary MacKillop Institute for Health Research in Melbourne, Australia. Nolan earned his BSc (Honours) in Biology at Butler University in 2007 and his PhD in Cellular and Integrative Physiology from Indiana University in 2012 in his hometown of Indianapolis, Indiana USA. He was named the Chancellor’s Scholar in 2012 as the top student in the Graduate School’s Doctoral Program and also received postgraduate training in the Business of Life Sciences at Indiana University Kelley School of Business. Nolan completed his postdoctoral research from 2012 to 2016 in Sydney, Australia at the Garvan Institute of Medical Research and University of Sydney. He was awarded the 2015 Australian Physiological Society’s Postdoctoral Research Publication Prize for research that uncovered the exercise-regulated signalling network in human skeletal muscle. Commencing his position at ACU in 2016, Nolan currently leads the Integrative Physiology Group within the Exercise and Nutrition Research Program and is regularly invited to speak at local, national and international scientific seminar series and conferences. Nolan’s multidisciplinary research involves molecular, cellular, biochemical, proteomic and physiological approaches aimed at identifying novel mechanisms by which exercise and nutrition influence metabolic health and disease. Within this scope, his research group utilises cellular, animal and human model systems to map and interrogate signaling networks and energy-sensing pathways such as AMP-activated protein kinase (AMPK) underlying whole-body and skeletal muscle metabolic homeostasis.

Select publications

• Nelson, M. E.*, Parker, B. L.*, Burchfield, J. G.*, Hoffman, N. J.*, Needham, E. J., Cooke, K. C., . . . James, D. E. (2019). Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry. EMBO J, e102578. doi:10.15252/embj.2019102578
• Janzen, N. R., Whitfield, J., & Hoffman, N. J. (2018). Interactive Roles for AMPK and Glycogen from Cellular Energy Sensing to Exercise Metabolism. Int J Mol Sci, 19(11). doi:10.3390/ijms19113344
• Leckey, J. J., Hoffman, N. J., Parr, E. B., Devlin, B. L., Trewin, A. J., Stepto, N. K., . . . Hawley, J. A. (2018). High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB J, 32(6), 2979-2991. doi:10.1096/fj.201700993R
• Hoffman, N. J. (2017). Omics and Exercise: Global Approaches for Mapping Exercise Biological Networks. Cold Spring Harb Perspect Med, 7(10). doi:10.1101/cshperspect.a029884
• Lee-Young, R. S., Hoffman, N. J., Murphy, K. T., Henstridge, D. C., Samocha-Bonet, D., Siebel, A. L., . . . Febbraio, M. A. (2016). Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle. Mol Metab, 5(11), 1083-1091. doi:10.1016/j.molmet.2016.09.002
• Kleinert, M., Parker, B. L., Chaudhuri, R., Fazakerley, D. J., Serup, A., Thomas, K. C., . . . Richter, E. A. (2016). mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3. Mol Metab, 5(8), 646-655. doi:10.1016/j.molmet.2016.06.007
• Hoffman, N. J.*, Parker, B. L.*, Chaudhuri, R., Fisher-Wellman, K. H., Kleinert, M., Humphrey, S. J., . . . James, D. E. (2015). Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metab, 22(5), 922-935. doi:10.1016/j.cmet.2015.09.001
• Chaudhuri, R.*, Sadrieh, A.*, Hoffman, N. J., Parker, B. L., Humphrey, S. J., Stockli, J., . . . Yang, J. Y. (2015). PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications. BMC Genomics, 16, 617. doi:10.1186/s12864-015-1820-x
• Stockli, J., Meoli, C. C., Hoffman, N. J., Fazakerley, D. J., Pant, H., Cleasby, M. E., . . . James, D. E. (2015). The RabGAP TBC1D1 plays a central role in exercise-regulated glucose metabolism in skeletal muscle. Diabetes, 64(6), 1914-1922. doi:10.2337/db13-1489
• Hoffman, N. J., Penque, B. A., Habegger, K. M., Sealls, W., Tackett, L., & Elmendorf, J. S. (2014). Chromium enhances insulin responsiveness via AMPK. J Nutr Biochem, 25(5), 565-572. doi:10.1016/j.jnutbio.2014.01.007

* Authors contributed equally

Projects

• Investigating AMPK energy-sensing mechanisms underlying metabolism and exercise
• Mapping and interrogating human exercise-regulated tissue and circulating biological networks