EX-HEART Trial

Exercise for heart health in prostate cancer.

Published August 20, 2018

About the EX-HEART research study

Everyday more than 45 men are diagnosed with prostate cancer in Australia. Androgen deprivation therapy (ADT) is an efficacious anti-cancer therapy that reduces prostate cancer mortality. However, ADT may increase the risk of cardiovascular morbidity and mortality. Improvements in prostate cancer treatment means that patients are living long enough to experience the late effects associated with ADT. Thus, cardiovascular disease is a significant issue faced by many men with prostate cancer. Against this background, there is a plethora of evidence in the cardiovascular medicine that may highlight the potential mechanisms contributing to cardiovascular disease, key diagnostic methods to identify those at the highest risk and the potential efficacy of exercise medicine to modify cardiovascular risk. The purpose of this pilot research study is to evaluate the impact of ADT on cardiovascular structure and function, as well as the impact of exercise training during ADT on cardiovascular structure and function.

Who is this trial for?

  • Men diagnosed with prostate cancer
  • 40 years or older
  • Scheduled or within one-month of ADT
  • All screening is performed by Ex-HEART trial staff at Australian Catholic University and Baker Heart and Diabetes Institute

 What does participation involve?

  • Comprehensive cardiovascular screening including echocardiography, cardiac magnetic resonance imaging and cardiopulmonary exercise test
  • 3-month best practice exercise intervention
  • Supervised by an accredited exercise physiologist who specialises in prostate cancer
  • Individualised exercise prescriptions
  • Small group exercise sessions
  • Delivered at one of four fitness centres around Melbourne
  • All screening and training is provided free of charge to participants
  • All participants will receive the exercise intervention with the control group offered a delayed intervention (wait list control)

Where are the exercise clinics?

  • Genesis Health and Fitness, Melbourne CBD
  • Coburg Leisure Centre, Coburg
  • Hawthorn Leisure Centre, Hawthorn
  • Monash University, Caufield

How do I get involved?

Register your interest to participate in the trial

 



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